David Haussler - Wikipedia
bioinformaticsgenomicshuman-genomeucsccomputational-biology
Abstraction: Bioinformatician who led first human genome sequence assembly at UCSC
Key points:
- Led team that computationally assembled the first draft human genome in 2000; grad student Jim Kent wrote key assembly code in ~4 weeks
- Pioneered use of Hidden Markov Models, stochastic context-free grammars, and kernel methods for DNA/RNA/protein sequence analysis
- Developed the UCSC Genome Browser (2002), widely used platform for biomedical research and large-scale genomics projects including ENCODE and Cancer Genome Atlas
- Introduced Vapnik-Chervonenkis (VC) dimension framework to computational learning theory with Blumer, Ehrenfeucht, and Warmuth
- Founding scientific director of UC Santa Cruz Genomics Institute; elected NAS (2006) and NAE (2018)
- Co-founded Genome 10K Project (now Vertebrate Genomes Project) targeting genomes of 10,000 vertebrate species
Connections: David Haussler · Ucsc · Bioinformatics · Computational Learning Theory · Genomics